Sanchez, 29, missed the 3-0 defeat to Tottenham Hotspur with a slight injury but he returns on the left wing with Romelu Lukaku and Jesse Lingard joining him in attack.
BURNLEY V MANCHESTER UNITED - LIVE!
Summer signing Fred drops to the bench with Marouane Fellaini starting in midfield whilst Juan Mata is left out of the squad entirely.
United come into the match under pressure following that loss to Spurs, with manager Jose Mourinho's press conferences becoming more erratic.
For Burnley Joe Hart keeps his place in goal with Tom Heaton on the bench.
18-year-old Dwight McNeil makes his debut on the left-wing.
TEAMS IN FULL
Burnley - Hart, Bardsley, Tarkowski, Mee, Taylor, Lennon, Cork, Hendrick, Westwood, McNeill, Wood
Manchester United - De Gea, Valencia, Lindelof, Smalling, Shaw, Fellaini, Matic, Pogba, Lingard, Lukaku, Sanchez
This article was written by cool news network.