Due to an NFL game being due to take place on Sunday 28 October, the game will be hosted on the following Monday.
The London club's three Champions League home games, against Barcelona on 3 October, PSV Eindhoven 6 November and Inter Milan 28 November, will also take place at Wembley.
Spurs released a statement saying that 'issues with the critical safety systems had resulted in the need to delay the opening of [the] new stadium."
Chairman Daniel Levy said: "We are all focused on ensuring contractors deliver our new stadium in the shortest possible period of time and opening our stadium at the earliest opportunity. The consequences of not being able to open our new stadium on 15 September against Liverpool have been immense. Building a venue of this scale that is open to the general public is a huge undertaking. We are creating, in Tottenham, a unique world class stadium with pioneering technology and engineering.
"Amongst the consequences of the delay have been substantial additional costs, not least of which the need for alternative venue hire, along with the inconvenience for our fans and those of our opposition.
"I want to apologise once again and thank you all for your support, many of you have taken the time to write to us and commend what we are doing for the Club. When you face times like this in an organisation it's teamwork and pulling together that gets you through."
This article was written by cool news network.